Inflammatory Infiltrates in Melanocytic Lesions

Inflammatory infiltrates are frequently present in melanocytic lesions, with different distribution and composition. Much attention has been devoted to tumor-infiltrating lymphocytes (TIL) the tumor microenvironment, establishing their prognostic predictive value many malignancies, including melanoma. However, lymphocytes, albeit most numerous consistent presence, constitute only part of immune microenvironment. Other inflammatory cells, neutrophils, plasma eosinophils mast found melanoma other lesions.Few studies offer a detailed count these across spectrum lesions. By using whole slide image analysis open source software, study we report enumeration benign nevi, dysplastic situ invasive malignant melanomas. Significant higher numbers cells neutrophils were observed These results indicate that composition infiltrate may contribute diagnostic algorithm